Figure 6.

Tumor permeability visualized and quantified over time by contrast-enhanced MRI. Enhancing fraction (representing Gd-permeable tumors) was quantified as the number of enhancing tumors relative to total tumor burden by assessment of T1w SE post-Gd (A) and bSSFP images (B). Black arrows indicate metastases that were detected in both the T1w SE and the bSSFP sequences; these were considered “enhancing.” White arrows indicate metastases that were detected in the bSSFP image but were absent in the corresponding post-Gd T1w SE image; these were considered “nonenhancing.” Over time, the enhancing fraction increased in both groups; treatment did not have any significant effect (C). Error bars represent standard deviation.