Enhancing and nonenhancing tumors respond differently to WBRT. In both untreated and WBRT-treated mice, enhancing tumors were larger than nonenhancing tumors at day 32 and at day 36 (statistical significance indicated by ••, •, °°, and °). By day 36, the mean volume of an enhancing tumor in a treated mouse was significantly less than untreated (*); however, there was no difference between groups in the volume of nonenhancing tumors. Error bars represent standard deviation.