Skip to main content
. 2016 May 5;594(12):3287–3305. doi: 10.1113/JP271809

Figure 9. Hypothetical model of mechanosensing in cardiomyocytes .

Figure 9

A, effects of myocyte cross‐bridge activity on MLP subcellular location. 1, increased cross‐bridge activity activates HO‐1. 2, activation of HO‐1 enables the translocation of MLP to the nucleus in response to myocyte contraction. Blebbstatin may be used to block cell contractility. MLP nuclear translocation can be blocked by PPZII, an inhibitor of HO‐1. 3, MLP translocates to the nucleus. 4, protein accumulates in the nucleus, resulting in decreased levels of the cytoplasmic protein and decreased mechanosensitivity. B, effects of passive stretch on MLP subcellular location. 1, passive stretch activates HDAC4 activity and its translocation out of the nucleus. 2, stretch also directly activates HO‐1 and indirectly through increased contractility (3). 4, HDAC4 in the cytoplasm interacts with and deacetylates MLP in the myofilaments. 5, deacetylated MLP alters myocyte contractility and calcium sensitivity. 6, deacetylated MLP is able to enter and exit the nucleus in response to cross‐bridge activity, meaning that the protein does not accumulate there.