Figure 9. Contractile responses to EFS in MYPT1‐deficient ileum .

A, representative force responses are shown for indicated EFS frequencies for ileal tissues from MYPT1^SM+/+ (upper trace), MYPT1^T853A (middle trace) and MYPT1^SM–/− (lower trace) mice. B, quantified maximum force‐frequency responses are shown for ileum from MYPT1^SM+/+ (open circles) and MYPT1^SM–/− (solid circles) mice. C, quantified forces following maximal responses with continuous 30 Hz EFS in ileal strips from MYPT1^SM+/+ (open circles) and MYPT1^SM–/− (solid circles) mice. D, quantified maximum force‐frequency responses in ileal strips from MYPT1^SM+/+ (open circles) and MYPT1^T853A (solid circles) mice. E, quantified forces following maximal responses with continuous 30 Hz EFS in ileal strips from MYPT1^SM+/+ (open circles) and MYPT1^T853A (solid circles) mice. Force measurements were normalized to the maximal developed forces marked as 0 s in (C) and (E). Data are the mean ± SEM (n ≥12 animals). **P < 0.01 and ***P < 0.001 compared to MYPT1^SM+/+ at the same time. The SEM bars may be smaller than the symbols for the means.