Figure 5. Effects of intrinsic neural inputs on Ca²⁺ transients in ICC‐DMP .

A, representative image of an ICC‐DMP and ST map showing spontaneous Ca²⁺ transients in the ICC‐DMP under control conditions (KRB perfusion of bath). B, application of TTX (1 μm) enhanced the occurrence of Ca²⁺ transients in the same ICC‐DMP, as shown in the ST map. C, summary data showing the increase in Ca²⁺ transients after the addition of TTX (**P = 0.01, n = 6). D, summary histograms showing the amplitudes of Ca²⁺ transients (in presence of TTX; red bars and line) compared to control conditions (black bars and line; P = 0.89, n = 6). E, summary histograms of the spatial spread of Ca²⁺ transients in the presence of TTX compared to control (P = 0.51, n = 6). F, application of caffeine (10 mm) elicited a global Ca²⁺ fluorescence rise throughout ICC‐DMP, as shown in the ST map, and the representative plot in G (♦) indicates a motion/focus artefact.