Figure 10. Effects of SERCA pump blockers on Ca²⁺ transients .

A, ICC‐DMP image and ST map of Ca²⁺ transients in the presence of TTX. Thapsigargin (10 μm) blocked Ca²⁺ transients as shown in the ST map in B. CPA (10 μm) also blocked Ca²⁺ transients in ICC‐DMP. C and D, summary data showing the effects of SERCA pump inhibitors on Ca²⁺ transients (CPA: ***P = 0.001, n = 5; thapsigargin: ***P = 0.001, n = 5). E and F, histograms showing the amplitudes and spatial spreads of Ca²⁺ transients in the presence of TTX (black bars and line) and after the addition of CPA (both ***P = 0.001, n = 5; red bars and line) or thapsigargin (both ***P = 0.001, n = 5; green bars and line).