Table 2.
Examples of scale up based research works on nanocrystals.
| Active/actives | Method | Media | Stabilizer/stabilizers | Refs. |
|---|---|---|---|---|
| Fenofibrate | Controlled crystallization during freeze-drying (made semi-continuous process by applying a 3-way nozzle) | Active in tertiary butyl alcohol and excipients in water | Matrix material, mannitol | de Waard et al. (2009) |
| Meloxicam | Media milling (and subsequent spray drying for characterization) | Water | Hydroxylpropyl methyl cellulose and sodium lauryl sulfate | Singare et al. (2010) |
| Apigenin (flavonoid) | Media milling and subsequent high pressure homogenization (smartCrystal combination technology – CT) | Water | Plantacare 2000® (alkyl polyglycoside) | Shaal et al. (2010) |
| Fenofibrate | Antisolvent precipitation coupled with immediate spray drying | Active in ethanol and excipients in water | Hydroxylpropyl methyl cellulose and sodium dodecyl sulfate | Hu et al. (2011) |
| Phenytoin, pranlukast hydrate and nifedipine | Media milling (and subsequent freeze drying for characterization) | Water | Polyvinyl pyrrolidine and sodium lauryl sulfate | Niwa et al. (2011) |
| Nevirapine | Comparison of high pressure homogenization and media milling (and subsequent air drying for characterization) | Water | Polyvinyl pyrrolidine, poloxamer 188, tween 80, volpoL4, and plasdone | Shegokar et al. (2011) |
| Nitrendipine | Precipitation-homogenization combination and further spray drying | Active in acetone and excipients in water | Polyvinyl alcohol | Quan et al. (2011) |
| NVS-102 (model drug) | Media milling (and subsequent freeze drying for characterization) | Water | d-α-tocopheryl polyethylene glycol 1000 succinate and hydroxylpropyl methyl cellulose | Ghosh et al. (2012) |