Table 2.

Advantages of micro-emulsion over emulsion (Holmberg et al. (2010).

Sr. no.	Conventional (macro) emulsion	Micro-emulsion
1
2	Two phase system renders it thermodynamically unstable	One phase system renders it thermodynamically stable
3	Poorer long term storage stability and often tend to coalesce, creaming/sedimentation or phase separation	Better long term storage stability
4	Comparatively less bioavailability	Reduction in dose by the enhancement in bioavailability
5	Comparatively less lipophilic transport	Enhanced lymphatic transport due to lipids Holm et al. (2003)
6	High intra and inter subject variability	Reduced intra and inter subject variability Gattefosse-self emulsifying formulation (2013)
7	Difficult manufacturing and scale up	Easy manufacture and scale up
8	Thermodynamically unstable	Excellent kinetic stability
9	Cloudy white	Clear
10	Large input of energy for method of preparation	No large input of energy for method of preparation
11	Globule size more than 500 nm	Micelle size are 5–500 nm