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. 2016 Jun 15;7:112. doi: 10.3389/fgene.2016.00112

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Copyright © 2016 Rosero, Villares and Bar-Eli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of protease activated receptor and chemokine receptor activation on several signaling pathways involved in melanoma metastasis. Abbreviations: MAPK, mitogen-activated protein kinase; PI3K, phosphoinositide 3 kinase; JAK, Janus kinase; PLC, phospholipase C; PIP2, phosphatidylinositol-bisphosphate; IP3, inositol triphosphate; DAG, diacylglycerol; PKC, protein kinase C; Cx-43, connexin-43; MMP, matrix metalloproteinase; VEGF, vascular endothelial growth factor; Ang-2, angiopoietin-2; CXCL1, CXC chemokine motif ligand 1.