Table 1.
The effect of early life maternal deprivation (MD) and mifepristone treatment on performance in the 5-choice serial reaction time task (5-choice SRTT) at the end of training (baseline).
| No-MD | MD | |||
|---|---|---|---|---|
| Vehicle | Mifepristone | Vehicle | Mifepristone | |
| Accuracy (%) | 94.08 ± 1.23 | 95.15 ± 0.86 | 93.42 ± 1.06 | 95.17 ± 0.77 |
| Omissions (#)b* | 8.00 ± 0.73 | 9.38 ± 0.84 | 7.33 ± 1.11 | 11.23 ± 1.41 |
| Premature (#) | 3.50 ± 1.15 | 5.15 ± 0.97 | 4.58 ± 0.58 | 4.50 ± 0.80 |
| Perseverant (#) | 3.75 ± 1.22 | 3.50 ± 0.91 | 5.38 ± 1.40 | 5.25 ± 1.18 |
| Latency to correct (s) | 0.74 ± 0.03 | 0.75 ± 0.03 | 0.74 ± 0.02 | 0.73 ± 0.02 |
| Latency to reward (s) | 1.12 ± 0.06 | 1.12 ± 0.05 | 1.19 ± 0.04 | 1.28 ± 0.07 |
| NP pellet hole ITI (#)a** | 302.8 ± 68.4 | 302.9 ± 48.4 | 155.0 ± 44.3 | 170.4 ± 30.6 |
| NP pellet hole/TO (#) | 2.33 ± 0.48 | 2.41 ± 0.26 | 1.98 ± 0.24 | 1.71 ± 0.24 |
| NP stimulus holes/TO (#)$ | 0.19 ± 0.03 | 0.21 ± 0.03 | 0.32 ± 0.06 | 0.27 ± 0.05 |
| Total duration (min) | 18.08 ± 0.27 | 18.38 ± 0.23 | 18.33 ± 0.24 | 18.73 ± 0.24 |
Data on general performance and stimulus (stimulus holes) and goal (pellet hole) approach in no-reward periods (NP: nose pokes, ITI: inter trial interval and TO: time-out). Data represent Mean ± SEM. Group sizes: No-MD vehicle (n = 8) and No-MD mifepristone (n = 16), MD vehicle (n = 8) and MD mifepristone (n = 16). amain effect of early life experience, bmain effect of mifepristone treatment. *p < 0.05, **p < 0.01, $main effect of early life with p = 0.052.