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. 2016 Jun 15;6:135. doi: 10.3389/fonc.2016.00135

Table 5.

Pathway activities for DLCL2 cells based on 13C LC-MS data.a

Pathway name Control Rapamycin P-value
Reductive carboxylation (cytosolic) 0.29 ± 0.05 0.17 ± 0.03 0.0235
Glutaminolysis 0.27 ± 0.10 0.014 ± 0.02 0.0122
Mitochondrial pyruvate carrier 0.63 ± 0.06 0.90 ± 0.09 0.0124
Pyruvate dehydrogenase complex 0.60 ± 0.07 0.56 ± 0.05 0.466
Pyruvate carboxylase (mitochondrial) 0.075 ± 0.030 0.39 ± 0.09 0.0045
De Novo fatty acid production 0.39 ± 0.07 0.23 ± 0.05 0.0322

aPresented as real parameter value ± error in terms of standard deviation (SD). Errors are based on Monte Carlo simulations assuming Gaussian noise with 0 mean and σ = 0.01 for SD; synthetic renormalized steady-state mass-isotopomers fit by fragmented cumomer model using Simplex.