Table 5.

Pathway activities for DLCL2 cells based on ¹³C LC-MS data.^a

Pathway name	Control	Rapamycin	P-value
Reductive carboxylation (cytosolic)	0.29 ± 0.05	0.17 ± 0.03	0.0235
Glutaminolysis	0.27 ± 0.10	0.014 ± 0.02	0.0122
Mitochondrial pyruvate carrier	0.63 ± 0.06	0.90 ± 0.09	0.0124
Pyruvate dehydrogenase complex	0.60 ± 0.07	0.56 ± 0.05	0.466
Pyruvate carboxylase (mitochondrial)	0.075 ± 0.030	0.39 ± 0.09	0.0045
De Novo fatty acid production	0.39 ± 0.07	0.23 ± 0.05	0.0322

^aPresented as real parameter value ± error in terms of standard deviation (SD). Errors are based on Monte Carlo simulations assuming Gaussian noise with 0 mean and σ = 0.01 for SD; synthetic renormalized steady-state mass-isotopomers fit by fragmented cumomer model using Simplex.