Table 4.
Significantly enriched pathways during PTG (Q-value < 0.05).
| Pathway | DEGs with pathway annotation (728) | All genes with pathway annotation (22,673) | P-value | Q-value | Pathway ID | |
|---|---|---|---|---|---|---|
| 1 | Alzheimer's disease | 28 (3.85%) | 350 (1.54%) | 9.95E-06 | 0.001746525 | ko05010 |
| 2 | Sphingolipid metabolism | 12 (1.65%) | 85 (0.37%) | 1.69E-05 | 0.001746525 | ko00600 |
| 3 | Galactose metabolism | 17 (2.34%) | 173 (0.76%) | 4.46E-05 | 0.002505594 | ko00052 |
| 4 | SNARE interactions in vesicular transport | 11 (1.51%) | 80 (0.35%) | 4.84E-05 | 0.002505594 | ko04130 |
| 5 | Epithelial cell signaling in Helicobacter pylori infection | 10 (1.37%) | 75 (0.33%) | 0.000137991 | 0.005712832 | ko05120 |
| 6 | Parkinson's disease | 20 (2.75%) | 263 (1.16%) | 0.00034861 | 0.012027028 | ko05012 |
| 7 | Huntington's disease | 26 (3.57%) | 394 (1.74%) | 0.000461303 | 0.01364138 | ko05016 |
| 8 | Pathogenic Escherichia coli infection –EPEC | 8 (1.1%) | 63 (0.28%) | 0.000885697 | 0.020371026 | ko05131 |
| 9 | Pathogenic Escherichia coli infection–EHEC | 8 (1.1%) | 63 (0.28%) | 0.000885697 | 0.020371026 | ko05130 |
| 10 | Gap junction | 11 (1.51%) | 113 (0.5%) | 0.001035227 | 0.021429199 | ko04540 |
| 11 | Phosphatidylinositol signaling system | 18 (2.47%) | 253 (1.12%) | 0.001444927 | 0.027190899 | ko04070 |
| 12 | ErbB signaling pathway | 9 (1.24%) | 85 (0.37%) | 0.001614039 | 0.027842173 | ko04012 |
| 13 | Inositol phosphate metabolism | 14 (1.92%) | 179 (0.79%) | 0.001977064 | 0.030086932 | ko00562 |
| 14 | Vibrio cholerae infection | 10 (1.37%) | 105 (0.46%) | 0.002034865 | 0.030086932 | ko05110 |
| 15 | Calcium signaling pathway | 15 (2.06%) | 204 (0.9%) | 0.002539515 | 0.032077558 | ko04020 |
| 16 | Glycolysis / Gluconeogenesis | 19 (2.61%) | 290 (1.28%) | 0.002767816 | 0.032077558 | ko00010 |
| 17 | Prostate cancer | 12 (1.65%) | 147 (0.65%) | 0.002841059 | 0.032077558 | ko05215 |
| 18 | Glycerophospholipid metabolism | 19 (2.61%) | 292 (1.29%) | 0.002985572 | 0.032077558 | ko00564 |
| 19 | Long-term potentiation | 14 (1.92%) | 188 (0.83%) | 0.003102072 | 0.032077558 | ko04720 |
| 20 | Oxidative phosphorylation | 23 (3.16%) | 383 (1.69%) | 0.003213484 | 0.032077558 | ko00190 |
| 21 | Melanogenesis | 14 (1.92%) | 189 (0.83%) | 0.003254245 | 0.032077558 | ko04916 |
| 22 | Ubiquitin-mediated proteolysis | 25 (3.43%) | 435 (1.92%) | 0.003869745 | 0.036410783 | ko04120 |
| 23 | Wnt signaling pathway | 15 (2.06%) | 215 (0.95%) | 0.004163601 | 0.036878991 | ko04310 |
| 24 | Axon guidance | 9 (1.24%) | 98 (0.43%) | 0.004275825 | 0.036878991 | ko04360 |