Figure 3.

Candidate Causal SNPs Are Located within a PRE that Interacts with the AKT1 and ZBTB42 Promoter Regions

(A) 3C interaction profiles between the PRE and local genes in Ishikawa and EN-1078D endometrial cancer cell lines. The 3C anchor (which contains the PRE) is shown as a grey box and significant interactions are outlined.

(B) Zoomed-in view of significant interactions. AKT1 Can and AKT1 Alt denote a canonical and alternative AKT1 promoter (prom) region, respectively. 3C libraries were generated with NcoI. Graphs represent three biological replicates. Error bars represent SD. Regions cloned into reporter gene constructs are shown as grey horizontal boxes.