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The Effect of PRDM6 Amino Acid Substitutions on Its Nuclear Localization
Immunofluorescence staining of wild-type PRDM6, PRDM6 p.Arg549Gln (p.R549Q), and p.Cys263Ser (p.C263S) in HEK293 cells. Whereas wild-type PRDM6 and p.Cys263Ser were localized in the nucleus, p.Arg549Gln was predominantly localized in the cytoplasm. Colors are as follows: blue, DAPI; green, phalloidin; and red, PRDM6 with FLAG tag. Scale bars represent 7 μm.
