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. 2016 Apr 21;173(13):2147–2161. doi: 10.1111/bph.13484

Figure 3.

Figure 3

Effect of (A) acute (0.1 and 1 mg·kg−1, i.p.) and (B) chronic (1 mg·kg−1, i.p., 14 days) administration of 5‐HT1A receptor agonist 8‐OH‐DPAT on the body temperature in B6‐M76B and B6‐M76C mice. Data are presented as mean ± SEM. In experiments for analysis of the acute 8‐OH‐DPAT effects (A), body temperature was measured 20 min after 8‐OH‐DPAT or saline administration (n = 8 per genotype per drug).* P < 0.05; ** P < 0.01; *** P < 0.001 versus saline group. In the experiment for the chronic 8‐OH‐DPAT effects (B), mice were treated with 8‐OH‐DPAT (1 mg·kg−1 – 8‐OH‐DPAT group) or saline (sham group) for 14 days. To reveal the effect of chronic 8‐OH‐DPAT treatment on the 5‐HT1A receptor‐mediated hypothermic response, after 14 days of treatment, all groups received a single i.p. injection of 8‐OH‐DPAT (1 mg·kg−1), and the body temperature was measured before and 20 min after this injection (n = 8 per genotype per drug). ** P < 0.01, ## P < 0.01 versus initial temperature of sham group. ns, non‐significant differences.