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. 2016 Apr 21;173(13):2147–2161. doi: 10.1111/bph.13484

Figure 4.

Figure 4

Effect of acute (A and B: 0.1 and 1 mg·kg−1, i.p.) and chronic (C and D: 1 mg·kg−1, i.p., 14 days) administration of 5‐HT1A receptor agonist 8‐OH‐DPAT on locomotor activity (distance run) (A, C) and exploration activity (number of rearings) (B, D) in the OF test in B6‐M76B and B6‐M76C mice. Data are presented as mean ± SEM. In the experiment for the analysis of the acute 8‐OH‐DPAT effects, the behaviour of mice in the OF test was estimated 20 min after 8‐OH‐DPAT or saline administration (n = 8 per genotype per drug). * P < 0.05; ** P < 0.01; *** P < 0.001 versus saline group. In experiments analysing the effects of chronic 8‐OH‐DPAT administration, the OF test was performed after daily injection of 8‐OH‐DPAT (1 mg kg−1 – 8‐OH‐DPAT group) or saline (sham group) for 14 days (n = 8 per genotype per drug); ** P < 0.01 versus saline (sham) group; # P < 0.05 versus B6‐M76B mice of 8‐OH‐DPAT group.