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. 2015 Dec 9;173(13):2095–2110. doi: 10.1111/bph.13343

Figure 1.

Figure 1

Long‐term (12 and 16 weeks) HFD induces anxiogenic‐like/depressive‐like phenotype. Centre entries (A) and time spent in the centre (B) in the OF, immobility time in the TST (C), grooming time in the ST (D), emotionality z‐score (E) integrating all these parameters (centre entries and time in the OF, immobility time in the TST and grooming time in the ST) in mice fed an STD (n = 14 and 10) or HFD (n = 12 and 10) for 12 (left panels) or 16 (right panels) weeks. *P < 0.05, significantly different from STD; two‐tailed Student's t‐test.