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. 2015 Dec 9;173(13):2095–2110. doi: 10.1111/bph.13343

Figure 3.

Figure 3

Long‐term (16 weeks) HFD impairs 5‐HT transmission. Basal 5‐HT extracellular levels (fmol∙sample−1) in the HPC (left panel) and AUC for 5‐HT extracellular levels over the 0–150 min period in mice fed the STD (n = 7) or HFD (n = 5) for 16 weeks (right panel) (A). Changes in body temperature induced by the 5‐HT1A receptor agonist 8‐OH‐DPAT (100 μg∙kg−1 s.c.). Data are expressed as percentage (%) of basal rectal temperature in mice fed an STD (n = 14) or HFD (n = 10) for 16 weeks (left panel) and percentage of decreased rectal temperature 30 min after 8‐OH‐DPAT administration (right panel) (B). Basal body temperatures were 36.2 ± 1 and 35.9 ± 0.8°C in STD‐fed and HFD‐fed mice respectively. *P < 0.05, significantly different from STD; two‐tailed Student's t‐test.