Figure 4.

Chronic escitalopram treatment does not modify metabolic parameters. Experimental protocol. Mice were fed as STD or HFD (STD vs. HFD) for 16 weeks and received during the last 4 weeks a s.c. injection of vehicle (Veh) or escitalopram (Esc; 10 mg·kg⁻¹·day⁻¹) (A). Final body weight (B), fasting blood glucose (C) and insulin (D) levels, change in blood glucose levels during an OGTT (E; inset: AUC of the glycaemia over the 120 min) and metabolic z‐score (F; parameters included are as follows: final body weight, fasting glycaemia and insulinaemia, AUC during the OGTT) in mice fed an STD treated with vehicle or escitalopram (n = 13 and 15), or fed an HFD treated with vehicle or escitalopram (n = 10 and 15). *P < 0.05, significantly different from corresponding STD value; one‐way ANOVA followed by Tukey's post hoc test.