Figure 5.

Chronic escitalopram treatment fails to reverse HFD‐induced anxiogenic‐like/depressive‐like phenotype. Centre entries (left panel) and time spent in the centre (right panel) in the OF (A), grooming time in the ST (B), latency to feed in the NSF test (C) and emotionality z‐score (D) integrating all these parameters (centre entries and time in the OF, grooming time in the ST and latency to feed in the NSF) in mice fed an STD treated with vehicle (Veh) or escitalopram (Esc; 10 mg·kg⁻¹·day⁻¹) (n = 13 and 15) or fed an HFD treated with vehicle (Veh) or escitalopram (Esc; 10 mg·kg⁻¹·day⁻¹) (n = 10 and 15). *P < 0.05, significantly different from corresponding STD, #P < 0.05, significantly different from corresponding Veh; NS P > 0.05. One‐way ANOVA followed by Tukey's post hoc test.