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. 2012 Jan 23;2012:823875. doi: 10.5402/2012/823875

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Copyright © 2012 Sara Iozzi et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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NCI8642 is able to compete with DKK1 in β-catenin translocation assay. (A) Panel a: Wnt3a-stimulated cells; panel b: cells treated with Wnt3a and DKK1; panel c: cells treated with Wnt3a, DKK1, and 50 μM NCI8642; panel d: cells treated with 50 μM NCI8642 only. (B) Concentration-response curve of NCI8642 (from 1 to 50 μM) expressed as % of activity. The activity was defined as the ratio of nuclear/cytoplasmic intensity normalized between Wnt3a + DMSO treatment (100% activity) and Wnt3a + DKK1 + DMSO treatment (0% activity).