Table 1.
List of studied SNP markers in the candidate genes.
| Chromosome | Nearest gene | Marker | MAF in CHB | MAF in CEU |
|---|---|---|---|---|
| 1p13.1 | VTCN1 | rs10158166 | 0.20 (T) | 0.12 (T) |
| rs1937956 | 0.11 (T) | 0.30 (T) | ||
| 1p13.2 | PTPN22 | rs1217385 | 0.17 (C) | 0.44 (A) |
| rs2488457 | 0.33 (C) | 0.22 (G) | ||
| rs1217414 | 0.12 (A) | 0.26 (A) | ||
| rs1217419 | 0.14 (G) | 0.48 (T) | ||
| rs3765598 | 0.20 (T) | 0.23 (T) | ||
| rs2476601 | 0.02 (A) | 0.12 (A) | ||
| 2q33 | CTLA4 | rs5742909 | 0.11 (T) | 0.08 (T) |
| rs231775 | 0.30 (A) | 0.39 (G) | ||
| rs3087243 | 0.20 (A) | 0.20 (G) | ||
| 6q25 | SUMO4 | rs6570965 | 0.39 (C) | 0.36 (A) |
| rs237027 | 0.17 (T) | 0.12 (T) | ||
| rs763590 | 0.10 (T) | 0.23 (T) | ||
| rs600739 | 0.49 (A) | 0.08 (G) | ||
| rs237025 | 0.20 (G) | 0.50 (G) | ||
| 9p24 | CD274 | rs702275 | 0.29 (G) | 0.48 (T) |
| rs822338 | 0.45 (T) | 0.23 (C) | ||
| rs2282055 | 0.39 (T) | 0.27 (G) | ||
| rs6415794 | 0.12 (A) | 0.48 (A) | ||
| rs2297137 | 0.46 (A) | 0.22 (A) | ||
| 10p15 | IL2RA | rs12251307 | 0.20 (T) | 0.10 (T) |
| rs4749955 | 0.34 (T) | 0.44 (C) | ||
| rs3118470 | 0.45 (T) | 0.31 (C) | ||
| rs706778 | 0.38 (C) | 0.40 (T) | ||
| rs2104286 | 0.11 (C) | 0.25 (C) | ||
| 11p15.5 | INS | rs689 | 0.05 (T) | 0.24 (T) |
| rs7924316 | 0.46 (T) | 0.41 (G) | ||
| rs1004446 | 0.33 (A) | 0.39 (A) | ||
| rs3741208 | 0.17 (A) | 0.36 (A) | ||
| 11q13.4 | DHCR7 | rs12785878 | 0.47 (G) | 0.27 (G) |
| 12p13 | CD69 | rs3136563 | 0.47 (G) | NA |
| rs4763879 | 0.48 (A) | 0.38 (A) | ||
| rs10844706 | 0.39 (A) | 0.39 (A) | ||
| rs917911 | 0.35 (T) | 0.34 (G) | ||
| 12q13 | ERBB3 | rs2292239 | 0.27 (T) | 0.33 (T) |
| rs705708 | 0.33 (A) | 0.50 (A) | ||
| rs2292238 | 0.38 (C) | 0.41 (C) | ||
| 12q13.11 | VDR | rs2228570 | 0.44 (A) | 0.41 (A) |
| rs7975232 | 0.31 (A) | 0.43 (C) | ||
| rs1544410 | 0.04 (T) | 0.44 (T) | ||
| 12q14.1 | CYP27B1 | rs4646536 | 0.24 (A) | 0.34 (G) |
| 15q23 | CD276 | rs11574483 | 0.11 (A) | 0.10 (A) |
| rs3825859 | 0.11 (A) | 0.07 (A) | ||
| 18p11.3 | PTPN2 | rs478582 | 0.15 (C) | 0.46 (C) |
| rs2542157 | 0.26 (G) | 0.43 (G) | ||
| rs2542151 | 0.15 (G) | 0.12 (G) | ||
| 21q22.3 | UBASH3A | rs2277798 | 0.40 (G) | 0.42 (A) |
| rs2277800 | 0.14 (T) | 0.04 (T) | ||
| rs9976767 | 0.28 (G) | 0.40 (G) | ||
| rs3827233 | 0.33 (C) | 0.41 (C) | ||
| rs2839519 | 0.16 (A) | 0.11 (A) | ||
| 22q13.1 | IL2RB | rs228942 | 0.26 (T) | 0.16 (T) |
| rs228941 | 0.37 (G) | 0.31 (G) |
Abbreviations: SNP: single nucleotide polymorphism; T1D: type 1 diabetes; MAF: minor allele frequency; MAF data were derived from Hapmap database (HapMap Public Release #27) and dbSNP build 146; CHB: Han Chinese in Beijing, China; CEU: Utah Residents with Northern and Western European Ancestry.