Table 2.
Allele and genotype frequencies of SNPs with significant association in patients with T1D and healthy controls.
| SNP | Allele/Genotype | T1D (%) n = 364 | Controls (%) n = 719 | OR (95%CI) | P value | Pcorr |
|---|---|---|---|---|---|---|
| INS-rs689 | T | 98.5 | 95.2 | 3.16 (1.65–6.68) | 0.01 | NS |
| A | 1.5 | 4.8 | 0.32 (0.15–0.61) | |||
| TT | 97.2 | 90.5 | 3.61 (1.82–7.97) | 0.002 | ||
| TA | 2.5 | 9.5 | 0.25 (0.11–0.51) | 0.0007 | ||
| AA | 0.3 | 0.0 | NA | NA | ||
| INS-rs1004446 | G | 75.8 | 71.3 | 1.26 (1.02–1.56) | 0.02 | NS |
| A | 24.2 | 28.7 | 0.79 (0.64–0.98) | |||
| GG | 59.9 | 50.5 | 1.47 (1.13–1.92) | 0.003 | ||
| GA | 31.7 | 41.5 | 0.65 (0.49–0.86) | 0.002 | ||
| AA | 8.4 | 8.0 | 1.06 (0.64–1.71) | 0.8 | ||
| INS-rs3741208 | G | 84.1 | 80.2 | 1.31 (1.03–1.68) | 0.008 | NS |
| A | 15.9 | 19.8 | 0.76 (0.60–0.98) | |||
| GG | 70.5 | 64.3 | 1.33 (1.00–1.76) | 0.05 | ||
| GA | 27.3 | 31.8 | 0.81 (0.60–1.07) | 0.1 | ||
| AA | 2.2 | 3.9 | 0.56 (0.22–1.28) | 0.2 | ||
| ERBB3-rs2292239 | G | 68.8 | 77.3 | 0.65 (0.53–0.79) | 0.0003 | 0.02 |
| T | 31.2 | 22.7 | 1.55 (1.26–1.90) | |||
| GG | 47.9 | 59.8 | 0.62 (0.48–0.81) | 0.0002 | ||
| GT | 41.7 | 35.0 | 1.33 (1.01–1.74) | 0.04 | ||
| TT | 10.4 | 5.2 | 2.12 (1.28–3.51) | 0.002 | ||
| PTPN2-rs2542151 | T | 78.5 | 83.5 | 0.72 (0.57–0.91) | 0.006 | NS |
| G | 21.5 | 16.5 | 1.39 (1.10–1.75) | |||
| TT | 61.0 | 69.6 | 0.68 (0.52–0.90) | 0.005 | ||
| GT | 35.1 | 27.9 | 1.40 (1.06–1.85) | 0.01 | ||
| GG | 3.9 | 2.5 | 1.58 (0.72–3.41) | 0.3 | ||
| UBASH3A-rs3827233 | G | 72.0 | 67.9 | 1.22 (1.00–1.49) | 0.02 | NS |
| C | 28.0 | 32.1 | 0.82 (0.67–1.00) | |||
| GG | 51.0 | 45.6 | 1.24 (0.95–1.61) | 0.1 | ||
| GC | 42.1 | 44.5 | 0.91 (0.70–1.18) | 0.5 | ||
| CC | 6.9 | 9.9 | 0.68 (0.40–1.11) | 0.1 |
Only significant results are shown. Abbreviations: SNP: single nucleotide polymorphism; T1D: type 1 diabetes; OR: odds ratio; 95% CI: 95% confidence interval; Pcorr: P value after Bonferroni correction (n = 55).