Fig. 2.

Analysis on drug–target interactions with FDA-approved drugs consisting of 5701 known interactions between 1242 FDA approved drugs and 1324 human protein targets. (a) #interactions versus #drugs, (b) #interactions versus #targets, (c) #shared targets versus average similarity between drugs and (d) #shared drugs versus average similarity between targets. In (c) and (d), the dashed lines show the trend lines, being fitted on a logarithmic function, and the two outside lines show the confidence interval of the estimation ((c): P  =  0.046, R² = 0.19 and (d): P  =  0.001, $R^2=0.57$)