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. 2016 Jun 11;32(12):i288–i296. doi: 10.1093/bioinformatics/btw274

Table 2.

Inferred parameters for simulated data (the correct parameter values are shown within parentheses)

Mechanistic ODE model and matrix Z
j Mechanism zj1 zj2 zj3 Rate param.
1 Basal activ. of A 1 1 1 0.012 (0.01)
2 Basal activ. of B 1 1 1 0.047 (0.05)
3 A activates B 1 0 0 6.410 (6)
4 B activates B 1 0 1 2.864 (2)
5 B activates C 0 1 0 0.633 (0.5)
6 C activates B 0 1 0 1.343 (1)
7 C activates D 0 0 1 0.096 (0.1)
8 D inhibits C 0 0 1 0.423 (0.5)
9 Degrad. of A 1 1 1 0.169 (0.15)
10 Degrad. of B 1 1 1 3.321 (2.5)
11 Degrad. of C 1 1 1 0.096 (0.05)
12 Degrad. of D 1 1 1 0.047 (0.05)
Latent process
Parameter Value Allowed range
λ1 0.950 (1) [0.25, 3]
τ1 8.387 (8) [2, 10]
λ2 0.491 (0.5) [0.25, 3]
τ2 18.057 (18) [12.5, 30]

In the statistical model, the parameters α and β have the values, 0.0001 and 0.1, respectively.