Table 2.
Mechanistic ODE model and matrix Z | |||||
---|---|---|---|---|---|
j | Mechanism | Rate param. | |||
1 | Basal activ. of A | 1 | 1 | 1 | 0.012 (0.01) |
2 | Basal activ. of B | 1 | 1 | 1 | 0.047 (0.05) |
3 | A activates B | 1 | 0 | 0 | 6.410 (6) |
4 | B activates B | 1 | 0 | 1 | 2.864 (2) |
5 | B activates C | 0 | 1 | 0 | 0.633 (0.5) |
6 | C activates B | 0 | 1 | 0 | 1.343 (1) |
7 | C activates D | 0 | 0 | 1 | 0.096 (0.1) |
8 | D inhibits C | 0 | 0 | 1 | 0.423 (0.5) |
9 | Degrad. of A | 1 | 1 | 1 | 0.169 (0.15) |
10 | Degrad. of B | 1 | 1 | 1 | 3.321 (2.5) |
11 | Degrad. of C | 1 | 1 | 1 | 0.096 (0.05) |
12 | Degrad. of D | 1 | 1 | 1 | 0.047 (0.05) |
Latent process | ||
---|---|---|
Parameter | Value | Allowed range |
λ1 | 0.950 (1) | [0.25, 3] |
τ1 | 8.387 (8) | [2, 10] |
λ2 | 0.491 (0.5) | [0.25, 3] |
τ2 | 18.057 (18) | [12.5, 30] |
In the statistical model, the parameters α and β have the values, 0.0001 and 0.1, respectively.