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. 2016 Jun 11;32(12):i128–i136. doi: 10.1093/bioinformatics/btw275

Fig. 1.

Fig. 1.

Overview of TimeTP analysis workflow. TimeTP uses an integrated network of GRN and PIN. Each biological pathway is analyzed by TimeTP and the perturbed sub-pathways are identified with the time-delay-bounded propagation of gene expression. The starting point or a gene of each perturbed sub-pathway is mapped to the integrated network and then regulators of the perturbed sub-pathways are identified by the labeled influence maximization algorithm