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. 2016 Jun 15;6:27985. doi: 10.1038/srep27985

Table 2. Canonical residues in FRs of VH & VL for back mutation.

Position Residues Interface core Loop foundation Loop interaction
LFR1 I4 0 1 1
LFR2 P47 1 1 0
LFR2 W48 0 1 0
LFR2 Y50 1 1 1
LFR3 Y72 0 1 1
HFR1 Y27 0 1 0
HFR2 I37 1 1 1
HFR2 K38 1 1 0
HFR2 I48 0 1 1
HFR3 A68 0 1 0
HFR3 L70 0 1 1
HFR3 G98 0 1 0

1 represents yes and 0 represents no, residues shown are original murine ones.