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. 2016 Jun 15;6:27907. doi: 10.1038/srep27907

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Healthy and diseased cattle and swine were assumed to be exposed to labeled therapeutic regimens of ceftiofur (A,B), enrofloxacin (C,D), flunixin (E,F), and sulfamethazine (G,H). The M/D ratios of studied drugs in the plasma and tissues of cattle and swine were predicted using the PBPK model. The labeled therapeutic regimens of these drugs are shown in Supplementary Table 9.