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. 2016 Jun 15;6:27871. doi: 10.1038/srep27871

Figure 3. Preferential accumulation of CD44-IR700 in CD44-high tumors.

Figure 3

(a) NIR fluorescence in vivo imaging of nude mice bearing bilateral tumors (upper, MDA-MB-231; lower, BT-474) over a 48-h period and fluorescence images of tumors, tumor slices and main organs at 48-h p.i. 50 μg of CD44-IR700 or IgG-IR700 or 1 nmol of IR700 injected i.v. In the petri-dish are MDA-MB-231 tumor (left), BT-474 tumor (right). Notations: T, tumor; H, heart; Li, Liver; S, spleen; Lu, lung; K, kidney; B, blood; M, muscle. (b) The IR700 fluorescence intensity and (c) the corresponding tumor to background ratio of MDA-MB-231 and BT-474 tumors over 48 hours after injection of compounds described in (a). Values represent mean ± SD (n = 4 per group, *P < 0.05, **P < 0.01 for MDA-MB-231 tumors from CD44-IR700-injected mice compared to the contralateral BT-474 tumors and MDA-MB-231 tumors from other control groups using Student’s t test).