Table 3.
Serum metabolic parameters in ND-fed and HFD-fed mice with and without CR.
| ND (n = 8) | HFD (n = 13) | HFD + CR (n = 15) | |
|---|---|---|---|
| Leptin (ng/ml) | 23.63 ± 1.97 | 44.44 ± 1.43* | 13.60 ± 1.19† |
| Insulin (ng/ml) | 0.47 ± 0.17 | 1.22 ± 0.18* | 0.32 ± 0.03† |
| Glucose (mg/dl) | 406.50 ± 49.82 | 505.77 ± 33.37* | 316.80 ± 24.00† |
| HOMA-IR | 7.40 ± 0.53 | 36.68 ± 5.08* | 6.22 ± 0.77† |
| Adiponectin (µg/ml) | 56.85 ± 13.72 | 31.11 ± 6.19* | 79.65 ± 10.94† |
| AST (U/l) | 106.25 ± 13.78 | 220.23 ± 10.98* | 124.13 ± 11.86† |
| ALT (U/l) | 43.00 ± 10.52 | 255.31 ± 24.02* | 23.60 ± 1.23† |
| Total cholesterol (mg/dl) | 131.25 ± 7.76 | 283.46 ± 10.41* | 141.53 ± 7.97† |
| Free fatty acid (µEq/l) | 1192.75 ± 51.36 | 1268.31 ± 47.72* | 1004.47 ± 58.61† |
The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from the fasting blood glucose (mmol/l) × fasting plasma insulin (µU/ml) divided by 22.5. Data are presented as the mean ± SEM. *P < 0.05 for HFD-fed versus ND-fed mice, †P < 0.05 for HFD+CR versus HFD-fed mice.