Table 4. Neural Structure by Trauma Exposure (N=58).
|
Trauma-exposed (n=22)a |
Controls (n=36) |
|||||||
|---|---|---|---|---|---|---|---|---|
| M | (SD) | M | (SD) | F(1,53)b | P-value | βc | P-value | |
| Volume (cc)3 | ||||||||
| Amygdala | 3993.8 | (379.5) | 4303.1 | (478.6) | 1.99 | 0.17 | −0.25* | 0.034 |
| Hippocampus | 9308.0 | (796.8) | 10 016.1 | (922.6) | 5.54* | 0.022 | −0.29* | 0.011 |
| Total brain volume | 1 500 413.2 | (143 873.9) | 1 587 849.7 | (186 016.3) | 8.15* | 0.006 | −0.26* | 0.013 |
| Thickness (mm) | ||||||||
| Dorsal ACC | 2.76 | (0.16) | 2.76 | (0.21) | 0.03 | 0.86 | 0.03 | 0.82 |
| vmPFC | 2.64 | (0.12) | 2.69 | (0.13) | 1.06 | 0.31 | −0.13 | 0.32 |
Abbreviations: ACC, dorsal anterior cingulate cortex; vmPFC, ventromedial prefrontal cortex.
Two trauma-exposed participants with MRI data did not finish the fear conditioning task.
Univariate ANOVA with trauma exposure as a between subjects and age, sex, and total brain volume as covariates, with the exception of the model for total brain volume, which controls for age and sex.
Regression examining trauma severity add a predictor of neural structure with age, sex, and total brain volume as covariates, with the exception of the model for total brain volume, which controls for age and sex.
*P<0.05, two-sided test.