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. 2016 Jan 13;41(8):1956–1964. doi: 10.1038/npp.2015.365

Table 4. Neural Structure by Trauma Exposure (N=58).

  Trauma-exposed (n=22)a
Controls (n=36)
       
  M (SD) M (SD) F(1,53)b P-value βc P-value
Volume (cc)3
 Amygdala 3993.8 (379.5) 4303.1 (478.6) 1.99 0.17 −0.25* 0.034
 Hippocampus 9308.0 (796.8) 10 016.1 (922.6) 5.54* 0.022 −0.29* 0.011
 Total brain volume 1 500 413.2 (143 873.9) 1 587 849.7 (186 016.3) 8.15* 0.006 −0.26* 0.013
 
Thickness (mm)
 Dorsal ACC 2.76 (0.16) 2.76 (0.21) 0.03 0.86 0.03 0.82
 vmPFC 2.64 (0.12) 2.69 (0.13) 1.06 0.31 −0.13 0.32

Abbreviations: ACC, dorsal anterior cingulate cortex; vmPFC, ventromedial prefrontal cortex.

a

Two trauma-exposed participants with MRI data did not finish the fear conditioning task.

b

Univariate ANOVA with trauma exposure as a between subjects and age, sex, and total brain volume as covariates, with the exception of the model for total brain volume, which controls for age and sex.

c

Regression examining trauma severity add a predictor of neural structure with age, sex, and total brain volume as covariates, with the exception of the model for total brain volume, which controls for age and sex.

*P<0.05, two-sided test.