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. 2016 Jan 20;41(8):1991–2000. doi: 10.1038/npp.2015.369

Figure 4.

Figure 4

Inhibition of S6K1 by PF-4708671 and FS-115 in Fmr1 KO mice rescues abnormal spine morphology. (a) Abnormal filopodial morphology in Fmr1 knockout (Fmr1 KO) mice was normalized by chronic administration of PF-4708671. **p<0.01 by Friedman non-parametric ANOVA, followed by Dunn's multiple comparison test. (b) Decreased mature spine morphology (stubby and mushroom spines) of Fmr1 KO mice was normalized by chronic administration of PF-4708671. **p<0.01 by Kruskal-Wallis non-parametric ANOVA, followed by Dunn's multiple comparison test. (c) Filopodial morphology of Fmr1 KO mice was normalized by chronic administration of FS-115. *p<0.05, **p<0.01, and ***p<0.001 by Kruskal-Wallis non-parametric ANOVA, followed by Dunn's multiple comparison test. (d) Decreased mature spine morphology (stubby and mushroom spines) in Fmr1 KO mice was normalized by chronic administration of FS-115. **p<0.01 and ***p<0.001 by Kruskal-Wallis non-parametric ANOVA followed by Dunn's multiple comparison test. n=3 mice (3–5 neurons per mouse, n=9–15 neurons per condition) for cohorts treated with either vehicle or PF-4708671. n=3 mice (4–6 neurons per mouse, n=12–18 neurons per condition) for cohorts treated with either vehicle or FS-115. For all graphs, error bars denote SEM. See also Supplementary Figure S4.