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. 2016 Feb 3;41(8):2052–2061. doi: 10.1038/npp.2016.2

Figure 1.

Figure 1

VU0409551 rescues synaptic plasticity deficits in the hippocampus of SR−/− mice. (a) Averaged graphs showing results of LTP experiments performed in slices from WT mice under control conditions (solid black circles, n=6 slices from two WT mice) and after VU551 treatment (red circles, n=7 slices from three WT mice). Insets show averages of 40 fEPSPs before (black trace) and 10 fEPSPs (thick gray trace) 45 min after LTP induction. (b) Results of LTP experiments in untreated slices (open circles, n=7 slices from four SR−/− mice) or slices treated with 30 μm VU0409551 (VU551; red filled circles, n=9 slices from five SR−/− mice). Insets show averages of 60 fEPSPs (black trace) before and 10 fEPSPs (gray trace) 45 min after LTP induction under both conditions (with or without the treatment of slices with VU551). (c) Summary of LTP results for the four experimental groups (white bars, vehicle; red bars, VU551). Data are presented as the mean±SEM. Significant two-way ANOVA results were followed up with Newman–Keuls multiple comparisons tests. Asterisk (*) indicates significant difference from the WT vehicle group (P<0.05) and ^ indicates significant difference from the SR−/− vehicle group. A full color version of this figure is available at the Neuropsychopharmacology journal online.