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. 2016 Feb 10;41(8):2062–2071. doi: 10.1038/npp.2016.3

Figure 2.

Figure 2

Removal of EtOH induces long-lasting depression-like behavior that requires an abstinence period. (a, b) Abstinence from EtOH significantly increases immobility time in the FST (a) 18 days, but not (b) 1 day, after EtOH removal. (c) Anxiety-like behavior in the EPM is unaffected 14 days after EtOH abstinence as measured by time spent in the open or closed arms of the apparatus. (c') Locomotion, measured by distance traveled in the EPM apparatus, is unaltered after 14 days of EtOH abstinence. (d) Depression-like behavior induced by EtOH abstinence is long-lasting. EtOH-exposed mice demonstrate depression-like behavior—increased latency to consume chow in the NSFT—at both 15 and 35 days following removal of EtOH. Data are represented as mean±SEM. **P<0.01; ***P<0.001.