Table 1.

Aptamers for small molecule targets described in literature from 2012 to 2015.

Target	Binding affinity [Kd (nM)]	Chemistry	Year	References
Digoxin	8–44	DNA	2012	Kiani et al., 2012
Kanamycin A	3900–24000	DNA	2012	Stoltenburg et al., 2012
Lysergamine	44–499	DNA	2012	Rouah-Martin et al., 2012
Sulfadimethoxine	84–150	DNA	2012	Song et al., 2012b
Trinitrotoluene (TNT)	not reported	DNA	2012	Ho et al., 2012
Abscisic acid	800–1000	DNA	2013	Grozio et al., 2013
Codeine	910	DNA	2013	Huang et al., 2013
N-acetylneuraminic acid	1.4	RNA	2013	Cho et al., 2013
N-glycolylneuraminic acid	6.7	DNA	2013	Gong et al., 2013
N-methyl-mesoporphyrin	1200–43000	DNA	2013	Yang and Bowser, 2013
Okadaic acid	77–983	DNA	2013	Eissa et al., 2013
Saxitoxin	133	DNA	2013, 2015	Handy et al., 2013; Zheng et al., 2015
Streptomycin	199–341	DNA	2013	Zhou et al., 2013
Xanthine	4200–18100	DNA	2013	Bae et al., 2013
Zearalenone	41	DNA	2013	Chen et al., 2013
17ß-Estradiol	900–124000	DNA	2014	Vanschoenbeek et al., 2015
17ß-estradiol	50	DNA	2014	Alsager et al., 2014
Aflatoxin B1	96–221	DNA	2014	Malhotra et al., 2014
Aflatoxin B1	650	DNA	2014	Zhu et al., 2014
Aflatoxin M1	35–1515	DNA	2014	Malhotra et al., 2014
Azobenzene-peptide	not reported	RNA	2014	Hayashi and Nakatani, 2014
Bromacil	9.6	DNA	2014	Williams et al., 2014b
Cortisol	7000–16000	DNA	2014	Martin et al., 2014
Cylindrospermopsin	57–180	DNA	2014	Elshafey et al., 2014
Danofloxacin	3–7.7	2′F-RNA	2014	Han et al., 2014
DFHBI-ITA	360	RNA	2014	Filonov et al., 2014
Kanamycin A	2800–163000	DNA	2014	Nikolaus and Strehlitz, 2014
Ketamine	590–660	DNA	2014	Sun M.Q. et al., 2014
Ochratoxin A	110–370	DNA	2014	McKeague et al., 2014
Oxytetracycline	4.9	DNA	2014	Kim et al., 2014
Progesterone	10–133	DNA	2014	Contreras Jiménez et al., 2015
Sphingosine-1-phosphate	4.3	L-RNA	2014	Purschke et al., 2014
T-2 toxin	20.8	DNA	2014	Chen et al., 2014
Thiazole orange	3.2	RNA	2014	Dolgosheina et al., 2014
Trinitrotoluene (TNT)	100	DNA	2014	Priyanka et al., 2014
17ß-estradiol	600	DNA	2015	Akki et al., 2015
17α-ethynylestradiol	500–1000	DNA	2015	Akki et al., 2015
Anatoxin-a	15–81	DNA	2015	Elshafey et al., 2015
Brevetoxin-2	42	DNA	2015	Eissa et al., 2015
DFHBI	not reportedB	RNA	2015	Zou et al., 2015
Dinitroaniline	100	RNA	2015	Arora et al., 2015
Melamine	510	DNA	2015	Gu et al., 2015
Quinolone	0.1–56.9	DNA	2015	Reinemann et al., 2016

Given are the K_d-values reported in the respective reference. For aptamers described between 1990 and 2012, refer to McKeague and Derosa (2012).

^A(Z)-4-(3,5-difluoro-4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one.

^BSelection was performed in bacterial cells to select for high fluorescence, not affinity.