Table 5.
HLA associations for cutaneous/muco-cutaneous leishmaniasis from case control studies conducted to-date
| Study | Location | Type of leishmaniasis | Sample size | Associations for susceptibility | Odds ratio (95 % confidence interval) or p value | Associations for resistance | Odds ratio (95 % confidence interval) or p value |
|---|---|---|---|---|---|---|---|
| Ribas-Silva et al. [16] 2013 | Brazil | Cutaneous | 160 patients | DRB1*13 | 1.66; (1.08–2.56) | B*45 | P = 0.01 |
| 270 controls | |||||||
| B*35 | 1.67 (1.08–2.29) | ||||||
| B*44 | 1.67 (1.05–2.64) | ||||||
| B*27 | 7.1111; (1.78–28.33) | ||||||
| B*49 | 6.4 (1.85–22.17) | ||||||
| B*52 | 12.61 (3.08–51.66) | ||||||
| A*02 B*44 DRB1*07 (haplotype) | P = 0.024 | ||||||
| A*24 B*35 DRB1*01 (haplotype) | P = 0.024 | ||||||
| Olivo-Diaz et al. [15] 2004 | Mexico | Cutaneous | 65 patients | DRB1*0407 | 2.92 (1.68–5.06) | DPB1*0401 | 0.38 (0.21–0.67) |
| 100 controls | |||||||
| DPA1*0401 | 10.07 (1.25–80.73) | DR2 (DRB1*15 and DRB1*16) | 0.14 (0.05–0.38) | ||||
| DPB1*0101 | 5.99 (1.98–18.16) | ||||||
| DQA*03011 | 2.14 (1.34–3.40) | ||||||
| DRB1*0407-DQA1*03011-DQB1*0302 (haplotype) | 2.26 (1.27–4.00) | ||||||
| DRB1*0407- DQA1*03011-DQB1*0301 (haplotype) | 6.94 (0.82–58.36) | ||||||
| Samaranayake et al. [51] 2016 | Sri Lanka | Cutaneous | 200 patients | DRB1*15 | p = 0.002, Pc = 0.01 | A*68 | P = 0.03; Pc = 0.31 |
| 200 controls | |||||||
| B*07 | P = 0.007; Pc = 0.13; OR = 0.36 (0.17–0.77 | ||||||
| DRB1*15-DQB1*06 (haplotype) | P = 0.00; Pc < 0.01; OR = 0.3 (0.2–.0.6) | ||||||
| DRB1*07-DQB1*02 (haplotype) | P = 0.03; Pc = 0.09 | ||||||
| DRB1*04-DQB1*02 (haplotype) | P = 0.03; Pc = 0.09 | ||||||
| Lara et al. [13] 1991 | Venezuela | Cutaneous | Family study of patients and unaffected family members (n-24 families) | A*28 | P = 0.0018 | B*15 | 0.0062 |
| Bw22 | P = 0.012 | ||||||
| DQB1*0302 | P = 0.036 | ||||||
| Bw22CF31 (haplotype) | P = 0.0076 | ||||||
| Bw22DR*11DQ*7 (haplotype) | P = 0.0163 | ||||||
| DQw3 | Pc = 0.036 | ||||||
| Petzl-Erler et al. [49] 1991 | Brazil | Muco-cutanous | 43 patients | DQB1*03 | p = 0.006 | DR2 (DRB1*15 and DRB1*16) | p = 0.004 |
| 111 controls | |||||||
| el-Mogy et al. [50] 1993a | Egypt | Cutaneous | 27 patients | A*11 | NA | ||
| B*5 | NA | ||||||
| B*7 | NA | ||||||
| Barbier et al. [17] 1987 | Asian refugees in French Guiana | Cutaneous | 32 cases | Cw7 | p = 0.01 | ||
| 55 controls |
a Full article was not available