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. 2016 Jun 14;17:464. doi: 10.1186/s12864-016-2669-3

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© Preston et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — A SNP near the promoter region of ugt-5 increases in frequency 44× after lab adaptation. A G > C transversion found at below 1 % frequency in the ancestral C. remanei population has a 44× increase in frequency after 23 generations of laboratory adaptation. This SNP maps to the promoter region of a gene predicted to be homologous to the C. elegans gene ugt-5, which codes for an enzyme responsible for the removal of drugs, toxins, and foreign substances. The top panel shows 500 sequencing reads from the ancestral (wild) population; the bottom panel shows 500 sequencing reads from the lab-adapted population. The non-reference SNP at position 127,723,967 of the caeRem3 genome is visible in orange