Table 1.
Characteristicsa of study participants according to body size at birth, childhood, early adulthood and middle age
| At birth (kg) | Relative size at age 10 years | Relative size at age 20 years | BMI (kg/m2) at about age 60 years | Total | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <2.5 | 2.5- < 3.5 | 3.5+ | Thin | Average | Plump | Small | Medium | Large | <25 | 25- < 30 | 30+ | ||
| Age (years) at baseline, mean (SD) | 59.4 (4.8) | 59.0 (4.8) | 59.2 (4.9) | 59.7 (4.9) | 59.6 (5.0) | 58.7 (4.8) | 59.1 (4.8) | 59.6 (4.9) | 59.8 (5.1) | 59.4 (5.0) | 59.7 (4.9) | 59.4 (4.8) | 59.5 (4.9) |
| BMI (kg/m2) at baseline, mean (SD) | 26.4 (4.9) | 26.0 (4.5) | 26.4 (4.8) | 25.5 (4.3) | 25.9 (4.3) | 28.0 (5.5) | 24.5 (3.7) | 25.6 (3.9) | 28.3 (5.3) | 22.5 (1.7) | 27.1 (1.4) | 33.9 (3.8) | 26.1 (4.6) |
| Highest socioeconomic tertile, % (N) | 31.7 (19,115) | 35.0 (84,935) | 34.2 (50,239) | 32.5 (80,151) | 34.4 (143,760) | 32.2 (37,814) | 34.6 (81,086) | 34.4 (103,215) | 31.3 (76,102) | 36.5 (131,033) | 32.8 (96,469) | 26.7 (35,213) | 33.5 (262,715) |
| Height (cm), mean (SD) | 160.2 (6.7) | 162.1 (6.5) | 163.9 (6.6) | 162.6 (6.9) | 162.2 (6.5) | 161.9 (6.7) | 159.9 (6.2) | 162.4 (6.3) | 164.3 (6.8) | 163.3 (6.5) | 161.7 (6.4) | 160.6 (7.0) | 162.3 (6.7) |
| Current smoker, % (N) | 12.4 (7,396) | 11.3 (27,134) | 12.1 (17,638) | 10.6 (25,924) | 12.3 (50,908) | 14.8 (17,231) | 12.9 (29,910) | 11.8 (34,998) | 11.9 (28,713) | 13.8 (49,008) | 11.3 (33,025) | 9.5 (12,397) | 12.2 (94,430) |
| Alcohol (drinks pw), mean (SD) | 4.8 (10.3) | 5.4 (9.6) | 5.4 (9.7) | 5.1 (10.0) | 5.2 (9.7) | 5.1 (9.9) | 5.6 (10.1) | 5.4 (10.0) | 4.5 (9.4) | 5.7 (10.0) | 5.1 (9.9) | 3.8 (9.1) | 5.2 (9.9) |
| Strenuous exercise > once a week, % (N) | 22.2 (13,051) | 23.8 (56,974) | 23.9 (34,562) | 22.1 (53,342) | 23.3 (95,787) | 22.5 (25,977) | 23.7 (54,594) | 23.4 (68,989) | 21.2 (50,630) | 27.0 (95,066) | 21.0 (60,546) | 15.7 (20,217) | 22.8 (175,829) |
| Birth weight (kg), mean (SD) | 2.0 (0.4) | 3.1 (0.3) | 4.0 (0.4) | 3.1 (0.7) | 3.3 (0.7) | 3.4 (0.7) | 3.1 (0.7) | 3.2 (0.7) | 3.3 (0.7) | 3.2 (0.7) | 3.2 (0.7) | 3.2 (0.8) | 3.2 (0.7) |
| Menarche age <12 years, % (N) | 24.0 (14,352) | 21.1 (50,852) | 21.5 (31,243) | 24.0 (14,352) | 21.1 (50,852) | 21.5 (31,243) | 17.3 (40,198) | 19.2 (56,937) | 25.0 (60,318) | 15.9 (56,446) | 21.8 (63,599) | 29.8 (38,896) | 20.4 (158,941) |
| Parity, mean (SD) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.0 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.0 (1.2) | 2.1 (1.2) | 2.3 (1.3) | 2.1 (1.2) |
| Ever user of HRT, % (N) | 54.8 (32,621) | 55.5 (133,676) | 54.8 (79,749) | 57.2 (139,309) | 52.8 (218,500) | 52.9 (61,613) | 59.3 (137,799) | 54.3 (161,254) | 49.2 (118,236) | 55.2 (196,036) | 54.5 (158,706) | 50.9 (66,406) | 54.2 (421,148) |
| Women, (N) | 60,728 | 244,507 | 147,792 | 248,149 | 420,954 | 118,428 | 236,233 | 302,100 | 245,081 | 361,418 | 296,682 | 132,934 | 791,034 |
| Hip replacement | |||||||||||||
| Cases (N) | 1,338 | 5,129 | 3,258 | 4,918 | 9,346 | 3,063 | 3,529 | 6,261 | 7,424 | 6,273 | 7,056 | 4,073 | 17,402 |
| Followup (years), mean (SD) | 8.6 (2.1) | 8.6 (2.0) | 8.6 (2.0) | 8.6 (2.0) | 8.6 (2.1) | 8.6 (2.1) | 8.6 (2.0) | 8.6 (2.1) | 8.6 (2.1) | 8.7 (2.0) | 8.6 (2.1) | 8.5 (2.1) | 8.6 (2.1) |
| Knee replacement | |||||||||||||
| Cases (N) | 1,537 | 5,283 | 3,420 | 6,061 | 9,187 | 2,970 | 3,621 | 5,953 | 8,525 | 3,532 | 7,395 | 7,370 | 18,297 |
| Followup (years), mean (SD) | 8.6 (2.1) | 8.6 (2.0) | 8.6 (2.0) | 8.6 (2.1) | 8.6 (2.1) | 8.6 (2.1) | 8.6 (2.0) | 8.7 (2.0) | 8.6 (2.1) | 8.7 (2.0) | 8.6 (2.0) | 8.4 (2.2) | 8.6 (2.1) |
aCharacteristics were reported at baseline, that is, at the same time as body size was reported except for socioeconomic status, height, strenuous exercise, menarche and parity which were based on data reported at recruitment about 3 years earlier