Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 14;47:64. doi: 10.1186/s13567-016-0346-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Representative histopathological changes in pigs challenged with CSFV Shimen strain. Five groups of pigs (n = 4) were immunized and challenged as described in the “Materials and methods” section. At 15 days post-challenge (dpc), various tissues (spleen, kidney, tonsils, lymph nodes and bladder) were collected from the challenged animals, fixed with buffered 4% formalin and subsequently embedded in paraffin wax. Tissue sections (around 4-μm thick) were prepared and stained with hematoxylin and eosin for histopathological examinations. In Groups D and E, severe hemorrhages in the lymph nodes, tonsils, spleen, kidney and bladder were indicated as arrows; in Group C, slight to moderate histopathological changes were found in some tissues, such as focal necrosis in the splenic parenchyma (arrow) and depletion of lymphocytes (arrow) in the white pulp in the spleen and hemorrhages (arrow) in the lymph nodes. All the pigs in Group A or B did not show any histopathological changes. CFU: colony forming units. Bars 50 μm.