Table 3.
Obtained MRSA-status at the end of the study, FAS and PPS results
| A. Full Analysis Set (FAS) of 300 subjects | |||||||
| Final MRSA-status n (%) | Interventional IMM-population | Inpatient control group | Chi-square test for final MRSA-status | ||||
| (N = 99) | (N = 201) | ||||||
| W/o skin alterations | With skin alterations | Total | W/o skin alterations | With skin alterations | Total | IMM-population vs. inpatient control group | |
| N = 39 | N = 60 | N = 99 | N = 65 | N = 136 | N = 201 | ||
| MRSA-free (3 neg. swabs series) | 27 | 19 | 46 | 8 | 16 | 24 | For all patients: p < 0.001 |
| (69 %) | (32 %) | (47 %) | (12 %) | (12 %) | (12 %) | ||
| Two negative swabs series | 0 | 1 | 1 | 8 | 11 | 19 | For patients without skin alterations: p < 0.001 |
| (2 %) | (1 %) | (12 %) | (8 %) | (9 %) | |||
| One negative swab series | 0 | 0 | 0 | 15 | 25 | 40 | |
| (23 %) | (18 %) | (20 %) | |||||
| Remainder MRSA-positive | 12 | 40 | 52 | 34 | 84 | 118 | For patients with skin alterations: p < 0.001 |
| (31 %) | (67 %) | (52 %) | (53 %) | (62 %) | (59 %) | ||
| Total MRSA-positve | 12 | 41 | 53 | 57 | 120 | 177 | |
| (31 %) | (69 %) | (53 %) | (88 %) | (88 %) | (88 %) | ||
| Chi-square test for final MRSA-status | Patients with and without skin alterations: p < 0.001 | Patients with and without skin alterations: p > 0.05 | |||||
| B. Per Protocol Set (PPS) of 138 subjects with completed decolonization + follow-up | |||||||
| Final MRSA-status n (%) | Interventional IMM-population | Inpatient control group | Chi-square test for final MRSA-status | ||||
| (N = 84) | (N = 54) | ||||||
| W/o skin alterations | With skin alterations | Total | W/o skin alterations | With skin alterations | Total | IMM-population vs. inpatient control group | |
| N = 36 | N = 48 | N = 84 | N = 14 | N = 40 | N = 54 | ||
| MRSA-free (3 neg. swabs series) | 27 | 19 | 46 | 7 | 16 | 23 | For all patients: p > 0.5 |
| (75 %) | (40 %) | (55 %) | (50 %) | (40 %) | (43 %) | ||
| Two negative swabs series | 0 | 0 | 0 | 5 | 6 | 11 | For patients without skin alterations: p > 0.5 |
| (36 %) | (15 %) | (20 %) | |||||
| One negative swab series | 0 | 0 | 0 | 0 | 7 | 7 | |
| (18 %) | (13 %) | ||||||
| Remainder MRSA-positive | 9 | 29 | 38 | 2 | 11 | 13 | For patients with skin alterations: p > 0.5 |
| (25 %) | (60 %) | (45 %) | (14 %) | (27 %) | (24 %) | ||
| Total MRSA-positve | 9 | 29 | 38 | 7 | 24 | 31 | |
| (25 %) | (60 %) | (45 %) | (50 %) | (60 %) | (57 %) | ||
| Chi-square test for final MRSA-status | Patients with and without skin alterations: p < 0.01 | Patients with and without skin alterations: p > 0.05 | |||||