Table 2.
Cox multivariate analyses of patient and disease related factors affecting OS, PFS, CIR, and NRM.
| OS | p-value | Hazard Ratio (95% CI) |
|---|---|---|
| Type of transplant | <0.0001 | 0.36 (0.22, 0.59) |
| Auto-SCT vs. allo-SCT | ||
|
| ||
| Age at transplant, years | ||
| >50 vs. ≤50 | 0.0007 | 2.50 (1.47, 4.26) |
|
| ||
| Disease sensitivity | ||
| Resistant vs. sensitive | 0.006 | 2.14 (1.24, 3.68) |
|
| ||
| PFS | ||
|
| ||
| Type of transplant | 0.001 | 0.48 (0.27, 0.72) |
| Auto-SCT vs. allo-SCT | ||
|
| ||
| Age at transplant, years | ||
| >50 vs. ≤50 | 0.001 | 2.36 (1.41, 3.93) |
|
| ||
| Number of prior chemo regimens | 0.026 | |
| 1 | 1.0 | |
| 2 | 2.09 (0.28, 15.78) | |
| ≥3 | 4.11 (0.53, 31.75) | |
|
| ||
| CIR | ||
|
| ||
| Type of transplant | 0.5945 | 0.83 (0.42, 1.64) |
| Auto-SCT vs. allo-SCT | ||
|
| ||
| Months from diagnosis to SCT | 0.0062 | 1.05 (1.01, 1.08) |
|
| ||
| Disease sensitivity | ||
| Resistant vs. sensitive | 0.0109 | 2.56 (1.24, 5.29) |
|
| ||
| NRM | ||
|
| ||
| Type of transplant | 0.0004 | 0.30 (0.16, 0.59) |
| Auto-SCT vs. allo-SCT | ||
OS (overall survival), PFS (progression free survival), CIR (cumulative incidence of relapse/progression), and NRM (non-relapse mortality). Reference groups are allo-SCT, age ≤ 50 years, sensitive disease, and one prior chemoregimen.