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Proposed cascade mechanism involved in phosphate control of actinorhodin and undecylprodigiosin biosynthesis. The involvement of the two-component system PhoR-PhoP has been confirmed (see the text). The cascade action of AfsR mediated by AfsS on actII-ORF4 and redD pathway-specific regulators is based on the results of Umeyama and coworkers (47). The inset shows the binding of phosphorylated AfsR to the afsS promoter.
