Table 4 . Data of Rated Pain From the Subscale of the FAOS Questionnaire Shown as Median (Min-Max)^a .

Questions of FAOS Subgroup	Placebo			HPLT, n=17	HPLT, n=18		Δ RP, P Values
	Base-Line	Follow-up	RP (95% CI) RV (95% CI)	Base-Line	Follow-up	RP (95% CI) RV (95% CI)
Pain 1. How often	3 (2-4)	3 (0-4)	-0.31 (-0.55 to -0.07) 0.11 (0.00 to 0.28)	3 (2-4)	2 (0-2)	-0.76 (-0.92 to -0.59) 0.06 (0.00 to 0.17)	‏-0.45; P=0.002
Pain, when 2. Twisting/pivoting	1 (0-3)	0 (0-3)	-0.21 (-0.39 to -0.04) 0.16 (0.00 to 0.40)	1 (0-3)	0 (0-3)	-0.49 (-0.67 to -0.31) 0.02 (0.00 to 0.07)	-0.28; P=0.126
3. Straightening fully	1 (1-3)	1 (1-2)	-0.15 (-0.33 to 0.02) 0.04 (0.00 to 0.14)	1 (0-4)	0 (0-2)	-0.45 (-0.63 to -0.26) 0.02 (0.00 to 0.05)	-0.30; P=0.054
4. Bending fully	1 (0-2)	1 (0-2)	-0.18 (-0.36 to 0.01) 0.02 (0.00 to 0.07)	1 (0-3)	0 (0-3)	-0.51 (-0.69 to -0.32) 0.00 (0.00 to 0.00)	-0.33; P=0.048
5. Walking on flat surface	1 (0-4)	1 (0-3)	-0.11 (-0.29 to 0.06) 0.16 (0.00 to 0.42)	2 (0-4)	0 (0-3)	-0.47 (-0.66 to -0.29) 0.11 (0.00 to 0.33)	-0.36; P=0.029
6. Going up or down stairs	2 (0-3)	1 (0-3)	-0.35 (-0.52 to -0.17) 0.46 (0.00 to 0.93)	2 (0-3)	1 (0-3)	-0.57 (-0.75 to -0.38) 0.20 (0.00 to 0.42)	-0.22; P=0.285
7. At night while in bed	0 (0-3)	0 (0-2)	-0.11 (-0.28 to 0.07) 0.00 (0.00 to 0.00)	0 (0-4)	0 (0-2)	-0.03 (-0.21 to -0.05) 0.01 (0.00 to 0.02)	-0.08; P=0.936
8. Sitting or lying	0 (0-3)	0 (0-1)	-0.13 (-0.31 to 0.05) 0.01 (0.00 to 0.05)	0 (0-3)	0 (0-3)	-0.23 (-0.42 to -0.05) 0.01 (0.00 to 0.04)	-0.10; p=0.465
9. Standing upright	0 (0-3)	1 (0-3)	0.16 (-0.02 to 0.33) 0.07 (0.00 to 0.22)	1 (0-3)	0 (0-3)	-0.52 (-0.71 to -0.34) 0.14 (0.00 to 0.37)	-0.36; P<0.0001

Abbreviation: FAOS, Foot and Ankle Outcome Score.

^aSystematic group changes are shown as RP (95%CI) and individual variability (dispersion in change) as RV (95%CI) from the Svensson method. Response alternative to question 1: Never (0), Monthly (1), Weekly (2), Daily (3), Always (4); question 2-9: None (0), Mild (1), Moderate (2), Severe (3), Extreme (4).