Skip to main content
. Author manuscript; available in PMC: 2016 Sep 16.
Published in final edited form as: Nature. 2016 Mar 16;531(7595):528–532. doi: 10.1038/nature17184

Figure 1. Niacinamide (Nam) supplementation restores normal post-ischemic response in PGC1α−/− mice.

Figure 1

a, Pre-ischemic normal morphology and b, swollen mitochondria inside tubular cell 24h after ischemia-reperfusion injury (IRI). Scale bar 200nm. c, Renal di-/tri-acylglycerols (DAGs, TAGs) 24h following sham or IRI (n=6/group). P-value by ANOVA. d,e, Oil Red O (pink) for fat in normal and post-ischemic kidneys, scale bar 20μm. f, serum creatinine wildtype (WT) vs PGC1α−/− (KO) mice (basal, n=7/group; post-ischemia, n=18/group). g,h, Volcano plots of kidney metabolites from KO vs. WT or IRI vs. sham (univariate p<0.05 for colored dots, n=6/group). i, Serum creatinine in post-ischemic WT vs. KO mice treated with vehicle (Veh, n=5) vs. Nam (n=9). Error bars SEM, *p<0.05, **p<0.01.