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. Author manuscript; available in PMC: 2016 Sep 16.
Published in final edited form as: Nature. 2016 Mar 16;531(7595):528–532. doi: 10.1038/nature17184

Extended Data Fig 7. Effects of PGC1α on renal metabolites and features of cisplatin nephrotoxicity.

Extended Data Fig 7

a–c, Relative renal NAD, β-OHB, and PGE2 concentrations in WT littermates vs. PGC1α−/− (KO) mice (n=6/group). d, Serum creatinine in genetic control mice for iNephPGC1α 24 h after IRI with vehicle vs. mepenzolate (MPN, 10 mg/kg IP) treatment (n=5/group). e, Serum creatinine in genetic control mice for iNephPGC1α 24 h after IRI with vehicle vs. indomethacin (INDO, 10 mg/kg IP) treatment (n=6/group). f, Transmission EM with cytochrome c oxidase enzyme histochemistry of proximal tubular cell 24 h following cisplatin exposure (25 mg/kg IP) demonstrating mitochondrial injury. Scale bar 500 nm. g, Relative renal Nam concentrations following cisplatin as in f. Error bars SEM, *p<0.05, **p<0.01, ***p<0.001.