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. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: J Intensive Care Med. 2014 Apr 14;31(3):187–192. doi: 10.1177/0885066614530659

Table 3.

Association Between Magnesium Concentration and Severe Lactic Acidosis.

Odds Ratio for Lactic Acidosis (Lactate > 4 mmol/L)
Mg < 1.6 1.6 ≤ Mg <1.8 1.8 ≤ Mg < 2.1 Mg ≥ 2.1 Per 1 mg/dL Increase in Mg
Model #1a 1.72 (1.48–2.00) <.001 1.14 (0.96–1.35) .14 Reference 1.18 (1.02–1.37) .03 0.87 (0.76–0.98) .02
Model #2b 1.56 (1.37–1.83) <.001 1.16 (0.97–1.38) .10 Reference 1.03 (0.89–1.21) .65 0.83 (0.72–0.93) .001
Model #3c 1.56 (1.32–1.84) <.001 1.15 (0.95–1.38) .14 Reference 0.99 (0.85–1.17) .94 0.79 (0.69–0.91) <.001

Abbreviations: ICU, intensive care unit; SAPS, Simplified Acute Physiology Score; SBP, systolic blood pressure.

a

Includes unadjusted magnesium.

b

Adjusts for age, gender, ethnicity, and SAPS score.

c

Adjusts for age, gender, ethnicity, SAPS score, comorbidities, ICU type, admission serum creatinine, SBP, and oliguria during first 24 hours of ICU care.