Figure 3.

Anti-platelet drugs counteract CD14^highCD16⁺ expansion induced by vaccination. The percentage change from baseline of CD14^highCD16⁻, CD14^highCD16⁺, and CD14^lowCD16⁺ cell count in each of the groups is reported in A, B, and C, respectively, with the absolute values at baseline and post-vaccination shown in the table (P-values were calculated using rank ANCOVA). Also shown is the prevalence of each monocyte subset (expressed as percentage over total monocytes) at baseline and post-vaccination in the different groups (E, F, and G). Graphs D and H show the correlation between percentage change in CD14^highCD16⁺ cell count and CD16 nMFI (on the top) and between CD14^highCD16⁺ and CD14^highCD16⁻ cell count (on the bottom). Values are reported as median and IQR. *P = 0.002; **P = 0.0002 vs. baseline within Group 4 using Wilcoxon matched-pairs signed-rank test.