Table 5. Correlation of AFP ratios with HCC progression based on serum ALT levels in patients who achieved complete response (CR).
| Etiology | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total (n = 343) | HBV (n = 271) | HCV (n = 33) | Non-viral (n = 39) | |||||||||
| Recurrence | Recurrence | Recurrence | Recurrence | |||||||||
| No | Yes | p | No | Yes | p | No | Yes | p | No | Yes | p | |
| Total (n = 343) | n = 108 | n = 235 | n = 85 | n = 186 | n = 8 | n = 25 | n = 15 | n = 24 | ||||
| AFP ratio, median (IQR) | 0.3 (0.1–0.7) | 1.2 (0.5–5.7) | <0.001* | 0.3 (0.1–0.7) | 1.3 (0.5–7.0) | <0.001* | 0.5 (0.2–1.4) | 1.0 (0.6–1.8) | 0.146* | 0.2 (0.1–0.6) | 1.0 (0.1–4.3) | 0.052* |
| AFP ratio, n (%) | <0.001† | <0.001† | 0.859† | 0.007† | ||||||||
| ≤ 1.0 | 98 (47.3) | 109 (52.7) | 78 (49.1) | 81 (50.9) | 6 (30.0) | 14 (70.0) | 14 (50.0) | 14 (50.0) | ||||
| 1.1–2.0 | 7 (19.4) | 29 (80.6) | 5 (17.9) | 23 (82.1) | 1 (16.7) | 5 (83.3) | 1 (50.0) | 1 (50.0) | ||||
| > 2.0 | 3 (3.0) | 97 (97.0) | 2 (2.4) | 82 (97.6) | 1 (14.3) | 6 (85.7) | 0 (0) | 9 (100) | ||||
| ALT ≤ 40 U/L (n = 256) | n = 95 | n = 161 | n = 77 | n = 125 | n = 4 | n = 16 | n = 14 | n = 20 | ||||
| AFP ratio, median (IQR) | 0.2 (0.1–0.6) | 1.2 (0.5–5.7) | <0.001* | 0.2 (0.1–0.6) | 1.4 (0.5–7.4) | <0.001* | 0.2 (0.1–0.5) | 1.0 (0.4–2.9) | 0.025* | 0.3 (0.1–0.6) | 1.0 (0.2–4.3) | 0.053* |
| AFP ratio, n (%) | <0.001† | <0.001† | 0.624† | 0.033† | ||||||||
| ≤ 1.0 | 90 (54.2) | 76 (45.8) | 73 (57.5) | 54 (42.5) | 4 (28.6) | 10 (71.4) | 13 (52.0) | 12 (48.0) | ||||
| 1.1–2.0 | 5 (22.7) | 17 (77.3) | 4 (21.1) | 15 (79.0) | 0 (0) | 1 (100) | 1 (50.0) | 1 (50.0) | ||||
| > 2.0 | 0 (0) | 68 (100) | 0 (0) | 56 (100) | 0 (0) | 5 (100) | 0 (0) | 7 (100) | ||||
| ALT > 40 U/L (n = 87) | n = 13 | n = 74 | n = 8 | n = 61 | n = 4 | n = 9 | n = 1 | n = 4 | ||||
| AFP ratio, median (IQR) | 0.6 (0.3–2.0) | 1.2 (0.5–5.3) | <0.001* | 0.7 (0.3–9.8) | 1.2 (0.5–7.0) | 0.399* | 1.3 (0.5–2.9) | 1.1 (0.7–1.4) | 0.938* | 0.2 (0.2–0.2) | 1.4 (0.1–4.5) | >0.999* |
| AFP ratio, n (%) | 0.511† | 0.676† | >0.999† | >0.999† | ||||||||
| ≤ 1.0 | 8 (19.5) | 33 (80.5) | 5 (15.6) | 27 (84.4) | 2 (33.3) | 4 (66.7) | 1 (33.3) | 2 (66.7) | ||||
| 1.1–2.0 | 2 (14.3) | 12 (85.7) | 1 (11.1) | 8 (88.9) | 1 (20.0) | 4 (80.0) | - | - | ||||
| > 2.0 | 3 (9.4) | 29 (90.6) | 2 (7.1) | 26 (92.9) | 1 (50.0) | 1 (50.0) | 0 (0) | 2 (100) | ||||
Abbreviations: AFP, alpha-fetoprotein; HBV, hepatitis B virus; HCV, hepatitis C virus; IQR, interquartile range.
*Mann-Whitney U test;
†Fisher’s exact test