Table 2. Lipid Measurements, Patients Who Received Placebo First Compared to Those That Received Pitavastatin First.
| Period of treatment | Lipid variables* (mg/dL) | Placebo (n = 12) | Pitavastatin (n = 12) | Mean difference (95% CI) | P-value |
|---|---|---|---|---|---|
| Baseline | TC | 257.6 (237.9, 277.3) | 239.9 (220.2, 259.6) | 17.8 (2.6, 32.9) | 0.022 |
| TG | 350 (191.9, 508) | 282 (123.9, 440) | 68 (60.2, 196.1) | 0.299 | |
| LDL | 146.3 (133.6, 159.1) | 144.7 (131.9, 157.4) | 1.7 (-9.2, 12.6) | 0.764 | |
| HDL | 44.8 (39.9, 49.7) | 43 (38.1, 47.9) | 1.8 (0.6, 4.2) | 0.140 | |
| 4 weeks | TC | 246.6 (226.9, 266.3) | 201.3 (181.5, 221) | 45.4 (30.2, 60.6) | <0.001 |
| TG | 292.5 (134.4, 450.5) | 246.5 (88.4, 404.5) | 46 (-82.2, 174.2) | 0.482 | |
| LDL | 142.5 (129.7, 155.3) | 111.6 (98.8, 124.4) | 30.9 (20, 41.8) | <0.001 | |
| HDL | 43.5 (38.7, 48.4) | 43.5 (38.6, 48.3) | 0.1 (-2.3, 2.5) | 0.945 | |
| 8 weeks | TC | 255.2 (235.4, 274.9) | 202.3 (182.6, 222.1) | 52.8 (37.6, 68) | <0.001 |
| TG | 334 (176, 492.1) | 250.8 (92.7, 408.8) | 83.3 (44.9, 211.5) | 0.203 | |
| LDL | 145.1 (132.3, 157.9) | 111.5 (98.7, 124.3) | 33.6 (22.7, 44.5) | <0.001 | |
| HDL | 43.7 (38.8, 48.6) | 44.9 (40, 49.8) | -1.2 (-1.2, 3.5) | 0.337 | |
| 12 weeks | TC | 246.3 (226.5, 266) | 207 (187.3, 226.8) | 39.2 (24, 54.4) | <0.001 |
| TG | 279.1 (121, 437.2) | 351.3 (193.2, 509.4) | -72.2 (-200.4, 56) | 0.269 | |
| LDL | 145.6 (132.8, 158.4) | 113.2 (100.4, 126) | 32.4 (21.5, 43.3) | <0.001 | |
| HDL | 44.2 (39.3, 49.1) | 45.3 (40.4, 50.2) | 1.1 (-1.3, 3.5) | 0.354 |
*Mean (95% CI).