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. 2016 Jun 15;11(6):e0156800. doi: 10.1371/journal.pone.0156800

Fig 1. IgG1 and IgG4 PV mAbs target epitopes within the same Dsg3 extracellular domains.

Fig 1

(A) F706 and F779 mAbs bind desmoglein 3 (Dsg3) but not Dsg1. Subclass-switched anti-human Dsg3 F706 and F779 IgG1 and IgG4 were tested by ELISA for binding to Dsg3 and Dsg1. Negative and positive controls were provided by the manufacturer. F71 IgG1 and b12 IgG4 antibodies served as isotype controls. (B) Deduced epitopes of IgG1 and IgG4 variants of PV mAbs show that mAb pairs recognize epitopes within the same Dsg3 extracellular domains.